Positron Emission Tomography (PET) Imaging of Glial Activation in Psychotic Disease States

Inclusion Criteria: * healthy volunteers 18-65 years of age * Patients diagnosed with recent onset schizophrenia (within 5 years of onset), 18-65 years of age * Patients diagnosed with recent onset bipolar disorder (within 5 years of onset of first mania), 18-65 years of age * screening laboratory tests will be obtained for subjects within a 10 day period prior to the PET study and the results must be within normal limits for gender and age. These tests will be repeated with a 7-day window following the PET study * EKG conducted within 10 day period prior to the PET study. The EKG will be repeated within 7 days following the study. * Subject agrees to return to the Hospital for a follow-up EKG and laboratory testing of blood and urine. * For females of childbearing potential, negative serum pregnancy test within a 10 day period prior to PET study. Exclusion Criteria: * history of recent nosocomial infection, * history of chronic neurological disorder, such as multiple sclerosis or epilepsy, or structural,central nervous system (CNS) abnormality such as stroke or arteriovenous malformation, * history of head injury with loss of consciousness \> 1 hour, * history of active substance abuse as defined by substance abuse including alcohol abuse over the 6 months prior to the study, * dependence on benzodiazepine medication * contraindications to MRI scanning to include pacemakers, metallic implants/prosthesis or prohibitive claustrophobia, etc. * contraindications to PET scanning to include pregnancy, etc. For females of childbearing potential, negative serum pregnancy test less than 10 days prior to PET study * ECG demonstrating the patient is not in a sinus rhythm or is having acute ischemia. * any medical condition that in the opinion of the study investigators would constitute a safety risk to the subject.