Lime Powder Regimen (LPR) for Prevention of Renal Stone Recurrence

Chulalongkorn University137 enrolled

Overview

Lime powder regimen (LPR) is a lime-derived composition enriches with citrate/citric acid and potassium. LPR was invented to treat the renal stone patients with high risk of stone recurrence after stone removal. LPR should have equal or higher efficacy and lower adverse effect than current standard medicine.

Lime powder regimen (LPR) is a mixture of lime-derive component with adjuvants containing high concentration of citrate, and moderate amount of potassium, magnesium and antioxidants. LPR was tested and verified to be very less toxic in cell culture and animal models. The clinical trial phase II showed that LPR reduced urinary metabolic abnormalities that enhance stone formation, such as hypocitraturia, hypokaliuria and acidified urine. Adverse effect of LPR was very low.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

137

Conditions

Urolithiasis

Interventions

Lime Powder RegimenDRUG

LPR and placebo were randomly given to subjects for 6 months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Renal stone patients who were identified and stone was removed by surgical method. Exclusion Criteria: * Chronic kidney disease, chronic liver disease, history of coronary artery disease, or person who takes any medication that alters urinary metabolic profiles

Locations (1)

Chulalongkorn University

Bangkok, Thailand

Outcomes

Primary Outcomes

Renal stone recurrence

The stone recurrence after surgical removal of stone that can be detected by CT scan

Time frame: 6 months

Data from ClinicalTrials.gov

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