Anti-reflux Mucosectomy (ARMS) is a Useful Therapy for Refractory Gastroesophageal Reflux Disease (RGERD)

Inclusion Criteria: 1. Full sufficiency in literacy 2. Be off proton pump inhibitor, antacids and prokinetics ≥ 2 weeks 3. Refractory gastroesophageal reflux disease Exclusion Criteria: 1. Severe heart, lung, and cerebrovascular disease 2. Severe hematopoietic system disease 3. Abnormal blood coagulation function 4. Oropharyngeal abnormalities 5. Severe spine malformation 6. In pregnancy and lactation at present, or plan to become pregnant within 2 years 7. Severe inflammation or huge ulcers in stomach 8. Mental and psychological disorde