Gammaglobulins Level is Predictive Factor of Evolution in Sarcoidosis

Rennes University Hospital78 enrolled

Overview

Evaluation of the rate of achievement of serum protein electrophoresis (PPE) in diagnosis in a retrospective cohort of patients at Rennes University Hospital

In 50% of cases, sarcoidosis is associated with polyclonal hypergammaglobulinemia. The other forms have a normal gamma globulin level. The level of gamma globulinemia has not yet been studied as an evolutionary predictive factor. Furthermore, there are disseminated granulomatoses sharing common characteristics with sarcoidosis, associated with Common Variable Immunodeficiency deficit (DICV) type Primary Immunodeficiency syndrome (DIP), thus occurring in hypogammaglobulinemic patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Sarcoidosis

Interventions

Analysis of gamma globulinBIOLOGICAL

Electrophoresis of proteins

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: \- Patients newly diagnosed with sarcoidosis Exclusion Criteria: * Comorbidity responsible for a change in the level of gamma globulin * Other etiology of granulomatosis

Locations (1)

CHU de Rennes

Rennes, France

Outcomes

Primary Outcomes

Study of gamma globulin level present in the blood at the time of diagnosis of sarcoidosis on disease activity

Electrophoresis rates of serum proteins

Time frame: Day 1

Study of gamma globulin level present in the blood at the time of diagnosis of sarcoidosis on the course of the disease

Electrophoresis rates of serum proteins

Time frame: Day 1

Data from ClinicalTrials.gov

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