This project investigates the effects of repetitive transcranial magnetic stimulation (rTMS) on neural circuits as a function of spatiotemporal parameters and brain state in order to better understand why the method works and how to improve its efficacy. Leveraging our expertise in application of TMS methodology during concurrent single neuron recording techniques in non-human primates and imaging and scalp potential techniques in humans, the investigators aim to resolve three interlocking problems in the design and application of rTMS: stimulation frequency, spatial targeting, and interactions with brain state.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Enrollment
27
1-10 Hertz rTMS will be administered
Duke University Medical Center
Durham, North Carolina, United States
Motion Perception Accuracy
Acute effect of a rTMS session on the performance for a motion task, as measured by accuracy (in percentage of correct responses)
Time frame: during each TMS session, up to 3 hours
Reaction Time
Acute effect of a rTMS session on the performance for a motion task, as measured by reaction time (in ms)
Time frame: during each TMS session, up to 3 hours
Activation of Cortical Networks During a Visual Motion Task.
Acute effect of a rTMS session on fMRI activation during a motion task, as measured by the change in BOLD signal
Time frame: during each TMS session, up to 3 hours
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