Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis

Johns Hopkins University20 enrolled

Overview

1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone. 2. To demonstrate inflammatory cytokine imbalance, i.e., increased pro-inflammatory cytokines. Presence of these abnormalities would make patients with ulcerative proctitis and proctosigmoiditis good candidates for future sacral nerve stimulation therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Inflammatory Bowel Diseases

Interventions

ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity indexOTHER

In this study, an electrocardiogram signal will be recorded for 30 min in the fasting state, and blood samples for inflammatory cytokines analysis (7 ml) will be taken at the end of the ECG recording; fecal samples will be taken on the experimental day before the study. In addition, ulcerative colitis disease activity index will be assessed using the Mayo scoring system.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * No any systemic diseases; * no proctitis or proctosigmoiditis; * no history of gastrointestinal surgery; * no symptoms of diarrhea or fecal urgency during the past 2 weeks; * not taking any medications except contraceptives during the past 2 weeks; * age 18-65. Exclusion Criteria: * None.

Locations (1)

Johns Hopkins University

Baltimore, Maryland, United States

Outcomes

Primary Outcomes

symptoms characteristics in ulcerative colitis patients

ulcerative colitis disease activity index will be assessed using the Mayo scoring system, which includes stool frequency, rectal bleeding, mucosal appearance at endoscopy and physician rating of disease activity. The patient will get a score from 0 to 20, with higher score indicating more severe disease.

Time frame: 1 day