The Influence of Perioperative Optimisation to the Hip Arthroplasty Outcomes

Inclusion Criteria: * Patients with osteoarthritis of the hip undergoing hip arthroplasty with spinal - epidural anesthesia * Age \>50 and \<85 years * ASA (American Society of Anesthesiology Classification) II physical status * Start of operation no later than 09:00 * Signed informed consent form Exclusion Criteria: * Age \<50 and \>85 yers * BMI (Body Mass Index) \<20 and \>40 kg/m2 * ASA I and ASA\>II physical status * History of a bleeding disorder * Anemia before surgery Hb\<110 g/l * Intravascular fluid infusion within 24 hours before study * Diabetes mellitus * Previous open hip surgery * Psychiatric illness (intake of other psychiatric medication than selective serotonin reuptake inhibitors) * Alcohol intake 5 U daily * Contraindication to spinal - epidural anesthesia * Surgery not by project surgeon * Start of operation later than 09:00 * Atrial fibrillation * Narcotic addiction * History of DVT (Deep Vein Thrombosis), thromboembolic complications, acute cardiac insufficiency * Participation in the other study