Comparison of Hematopoietic Stem Cell Activity in Adipose Tissue From Type 2 Diabetic Patients and Healthy Volunteers

Inclusion Criteria: * No major weight variation for at least 3 months * Biological assessment without clinically significant anomaly from the point of view of the investigator. * Acceptance of constraints related to participation in the study * Acceptance of participation in the constitution of a cell bank, a tissue bank and a serum library. * Affiliation to a social security scheme. Type 2 diabetic subjects: * Type 2 diabetes (discovered after the age of 35 years, without inaugural ketosis and absence of insulin therapy during the first year). * 40 to 60 year-old. * BMI between 27 and 35 kg / m² (included). * Treated by modification of lifestyle alone or associated to oral anti-diabetic therapy only. * With stable oral anti-diabetic treatment for at least 3 months. * HbA1c ≤ 8.5%. Healthy Volunteers: * BMI between 23 and 27 kg / m² (included). * 37 to 63 year-old, age-matched to a type 2 diabetes subject ± 5 years. * Fasting blood glucose \< 1,10 g / L. * HbA1c within normal limits (4 to 6%). Exclusion Criteria: * Excessive chronic alcohol consumption (\> 30 g / day or 210 g / week). * Tobacco consumption\> 10 cigarettes / day that cannot be stopped for 24 hours. * Anti-diabetic treatments that require sub-cutaneous injections * History of chronic or acute hematological pathology. * Systemic or acute inflammatory pathology. * Treatment with antiplatelet agents, non-steroidal anti-inflammatory drugs, glucocorticoids (excluding eye drops and sprays), or other immunosuppressive drugs. * History of cancer (except basal cell carcinoma). * Allergy to xylocaine or one of its derivatives. * Any significant pathology at the discretion of the investigator. * Any biological anomaly at the discretion of the investigator. * Positive human immunodeficiency virus serology. * Positive hepatitis B serology. * Positive hepatitis C serology. * Glomerular filtration rate less than 60 ml / min * Aspartate aminotransferase or alanine aminotransferase higher than 2.5-fold the upper normal value. * Hypertriglyceridemia \> 2.5 g / l * Person under the protection of justice, guardianship or curators. * Subject involved in another research protocol or in an exclusion period from another research protocol. * Cognitive disorder or mental pathology (at the discretion of the investigator).