Impact of Branched-chain Amino Acids in the Development of Insulin Resistance

German Diabetes Center12 enrolled

Overview

The purpose of this study is to clarify the role of the branched-chain amino acids in the development of Insulin resistance in patients with diabetes

The proposed project aims to elucidate the role of the BCAA in the development of insulin resistance and type 2 diabetes. The project tests the hypothesis that a diet induced decrease of BCAAs concentrations alter the metabolic mechanisms involved in the control insulin resistance and diabetes progression. The specific aims are to elucidate the effect of the diet induced decrease of BCAAs concentrations on (I) peripheral and hepatic insulin sensitivity (II) ectopic fat distribution (III) energy metabolism (IV) metabolic and inflammatory status

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

Conditions

Diabetes

Interventions

Branched-chain amino acids reduced intakeDIETARY_SUPPLEMENT

Eligibility

Sex: ALLMin age: 30 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diabetes type 2 * Non smokers * Untrained * Willingness to adhere to a diet intervention Exclusion Criteria: * Chronic disease * Pregnancy * Cancer * Antibiotic therapy * Drug/alcohol abuse * Competitive athletes

Locations (1)

German Diabetes Centre

Düsseldorf, Germany

Outcomes

Primary Outcomes

Clamp test

Insulin sensitivity test

Time frame: up to 24 weeks

Secondary Outcomes

Mixed Meal Test

B cell function test

Time frame: up to 24 weeks

Data from ClinicalTrials.gov

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