The objective of this acute intervention study is to examine the potential of minerals combined with botanicals to demonstrate unique and synergistic effects on oscillatory brain activity, cognitive performance, and stress reduction (endocrine, sympathetic, and subjective parameters) under conditions of acute stress in moderately stressed individuals
Botanicals in isolation or combined, will be administered with a mineral and vitamin complex to moderately stressed, healthy adults in a parallel groups fashion in this randomised placebo controlled trial. Oscillatory brain activity (EEG) during rest and performance on cognitive tasks of attention will be examined after treatment intake under conditions of acute laboratory stress. The effects of treatments on stress responses (cardiovascular, subjective and cortisol responses) will also be assessed.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
100
A mineral and vitamin tablet
Botanical extract administered in capsule form
Botanical extract administered in capsule form
Human Appetite Research Unit, University of Leeds
Leeds, West Yorkshire, United Kingdom
Oscillatory brain activity during the rested state and attentional processing (EEG; Biosemi Active2, 64-channel, DC amplifier, 24-bit resolution system)
The effect of treatment on oscillatory brain activity during the rested state and during attentional task processing after stress exposure
Time frame: 30 minute period, approximately 65 minutes post treatment intake
Subjective stress (Stress & Arousal Checklist; Mackay et al., 1978)
The effect of treatment on subjective stress responses to stress induction
Time frame: Acute responses to stress induction from pre-treatment intake to approximately 8 hours post-treatment intake
Subjective mood (Profile of Mood States [MCNair et al., 1971] & Bond Visual analogue scales, 1974)
The effect of treatment on subjective mood responses to stress induction
Time frame: Acute responses to stress induction from pre-treatment intake to approximately 8 hours post-treatment intake
Subjective anxiety (Spielberger State Trait Anxiety Inventory, 1983)
The effect of treatment on subjective anxiety responses to stress induction
Time frame: Acute responses to stress induction from pre-treatment intake to approximately 8 hours post-treatment intake
Cognitive performance (Digit attention switching & threat vs neutral dot probe task)
The effect of treatment on reaction time and accuracy performance on two cognitive tasks of attention
Time frame: 20 minute period (comprising two distinct tasks) approximately 75 minutes post treatment intake
Blood pressure
The effect of treatment on blood pressure responses to stress induction
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Cellulose crystalline tablet
Time frame: Acute responses to stress induction from pre-treatment intake to approximately 8 hours post-treatment intake
Heart rate
The effect of treatment on heart rate variability before and after stress induction
Time frame: Acute responses to stress induction from pre-treatment intake to approximately 8 hours post-treatment intake
Salivary cortisol
The effect of treatment on salivary cortisol responses to stress induction
Time frame: Acute responses to stress induction from pre-treatment intake to approximately 8 hours post-treatment intake
Event related potentials (EEG; Biosemi Active2, 64-channel, DC amplifier, 24-bit resolution system)
The effect of treatment on event related potentials during execution of attentional processing
Time frame: 20 minute period (comprising two distinct tasks) approximately 75 minutes post treatment intake