Pivotal Study to Evaluate the Safety and Efficacy of GelrinC for Treatment of Cartilage Defects

Main Inclusion Criteria: * Age between 18 and 50. * Single contained symptomatic lesion located on the femoral condyle of the femur graded as ICRS III or IV with less than 5 mm of bone loss below the subchondral plate. * Lesion size between 1 and 5 cm2 post debridement, less than or equal to 2.5 cm in diameter. * BMI ≤35 * Contralateral knee is asymptomatic, stable, fully functional and not medically treated. Main Exclusion Criteria: * Presence of an additional grade III or IV symptomatic lesion. * Recent Osteochondritis Dissecans within 1 year of baseline visit. * Untreated ACL and/or PCL deficiency or Complex ligamentous instability of the knee. * Patient is excluded if presenting untreated current meniscal tear or if previous menisci resection was within the last 6 months. * Previous tendon repair or ligament reconstruction within the last 6 months. * Failed Mosaicplasty or ACI or MACI or any other cartilage repair product. * Microfracture performed less than 1 year before baseline visit.