The current project aims to investigate the trajectories of the visual imaging cognitive training (CT) and alphabet search training using fMRI in patients with amnestic mild cognitive impairment (MCI) and healthy elderly controls (HE). MCI patients will be grouped according to biomarkers (PET PIB).
We will include 40 subjects with amnestic mild cognitive impairment (MCI) multiple domain clinical diagnostic, over 60 years old, recruited through the outpatient clinic of University of Sao Paulo General Hospital. We will also include 20 healthy subjects, over 60 years old, recruited in the community. All the participants will be evaluated by neurologists specialized in cognitive neurology and subjected to a neuropsychological assessment. The 40 participants with MCI and 20 healthy subjects will receive 6 sessions of visual imaging training. After this first study, they will receive cognitive training with alphabet search training. This will be a longitudinal study. MCI patients will be grouped according to biomarkers (PET PIB).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
60
In the first phase of the study all participants will receive visual memory training. In the second phase they will receive alphabetic search training
University of Sao Paulo
São Paulo, São Paulo, Brazil
Results from task performance in functional magnetic resonance imaging (fMRI)
fMRI behavioral performance
Time frame: Baseline, after CT, and 12 months later
Changes in cognitive measures and brain activation
Logical Memory Test I and II, RAVLT I e II, brain activity, generalization tasks
Time frame: Baseline, after CT e 12 months follow-up
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