Revascularization StrategIes for ST Elevation Myocardial Infarction Trial

Inclusion Criteria: * ST elevation myocardial infarction evidenced by new ST elevation at the J point in at least 2 contiguous leads of ≥ 2 mm (0.2mV) in men or ≥ 1.5mm (0.15mV) in women in leads V2-V3 and/or ≥ 1mm (0.1mV) in other contiguous chest leads or limb leads. * MVD as evidenced by \> one significant (\>70% by visual assessment or FFR \< 0.80 for 50-70% stenosis) stenosis in the non-IRA \>2mm in diameter. * Successful IRA-PCI with \<30% residual angiographic stenosis and TIMI III flow * Written informed consent Exclusion Criteria: * Age ≤ 18 years * Prior coronary artery bypass graft (CABG) surgery * Administration of thrombolytic therapy. * Hemodynamic instability as evidenced by SBP\<90 mmHg, Killip class ≥3, and/or need for inotropes/vasopressors. * Known renal insufficiency (estimated GFR \< 30 ml/min/1.73m2) * Non-IRA stenosis is a chronic total occlusion (CTO) * Plan by treating physician to treat non-IRA stenosis with coronary artery bypass surgery