The main purpose of the study is to assess the mechanisms of repeated sessions of repetitive trancranial magnetic stimulation (rTMS) applied on left dorsolateral prefrontal cortex on the development of pain in a prolonged muscle pain model.
This study aims to investigate whether i) rTMS of left DLPFC will reduce the severity and duration of experimentally induced muscle pain when a 5-day course of treatment is given immediately following an initial nerve growth factor (NGF) injection; ii) the analgesic effects of left DLPFC rTMS will be related to an improved cognitive network function as assessed by electroencephalography (EEG).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
30
Repetitive trancranial magnetic stimulation is applied on the dorsolateral prefrontal cortex. The protocol consists on 20 minutes of 10Hz stimulation, 5 seconds on, 10 seconds off, at 110% RMT, for a total of 4000 pulses.
A sham coil is used to mimic the clicking sound of the trancranial magnetic coil and skin stimulation.
Aalborg University
Aalborg, North Denmark, Denmark
Pain relief
Pain on an 11-point numerical rating scale (0 = no pain, 10 = most intense pain imaginable)
Time frame: Change from baseline at 2 weeks
Muscle soreness
7-point Likert scale; 0 = 'a complete absence of soreness', 1 = 'a light soreness in the muscle felt only when touched/vague ache', 2 = 'a moderate soreness felt only when touched/a slight persistent ache', '3 = 'a light muscle soreness when lifting or carrying objects', 4 = 'a light muscle soreness, stiffness or weakness when moving the wrist without gripping an object', 5 = 'a moderate muscle soreness, stiffness or weakness when moving the wrist', 6 = 'a severe muscle soreness, stiffness or weakness that limits the ability to move'
Time frame: Change from baseline at 2 weeks
Patient-rated Tennis Elbow Evaluation
The Patient-rated Tennis Elbow Evaluation will be used to assess average pain and disability of the injected arm
Time frame: Change from baseline at 2 weeks
Attention network test
This task assesses cognitive function in 3 domains: alerting, orienting, and executive function
Time frame: Change from baseline at 2 weeks
Pressure pain thresholds
Pressure applied to the surface of the skin using a handheld algometer.
Time frame: Change from baseline at 2 weeks
Cuff pressure algometry
The experimental setup consists of a tourniquet cuff, a computer-controlled air compressor and an electronic visual analog scale VAS (Aalborg University, Denmark). The cuff is connected to the compressor and wrapped around the leg. The pain intensity is recorded with the electronic VAS and sampled at 10 Hz. The "0 cm" and "10 cm" extremes on the VAS are defined as "no pain" and as "maximal pain", respectively. The compression rate of the cuff is programmed on and controlled by a computer.
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Time frame: Change from baseline at 2 weeks
EEG recordings
we will record brain activity in the following conditions: eyes closed rest, performance of a computer-based cognitive task (ANT).
Time frame: Change from baseline at 1 weeks