Green Coffee Extract Supplementation and Oxidative Stress, Systemic and Vascular Inflammation

National Nutrition and Food Technology Institute48 enrolled

Overview

Metabolic syndrome (Mets) is defined as the collection of risk factors contributing to type 2 diabetes mellitus and cardiovascular disease. Mets is accompanied by oxidative stress and low-grade inflammation. Green coffee is rich in polyphenols called chlorogenic acids (CGA) which possess anti-inflammatory and anti-oxidative characteristics. Thus, we carried out this trial to examine green coffee extract (GCE) effects on oxidative stress, systemic and vascular inflammation in patients having Mets

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

DOUBLE

Enrollment

Conditions

Metabolic Syndrome

Interventions

green coffee extractDIETARY_SUPPLEMENT

Patients in treatment group take 400 mg GCE supplements twice a day for tow month

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * body mass index of over 25, waist circumference \>102 cm in men or \>88 cm in women,Fasting blood glucose \>100 mg/dL, Triglycerides (TG) \> 150 mg/dL, High density lipoprotein cholesterol (HDL-C) \<50 in women or \<40 in men, Systolic blood pressure (SBP) \>130 mmHg and diastolic blood pressure (DBP) \>85mmHg Exclusion Criteria: * insulin administration for diabetes control, having hypo- or hyperthyroidism, renal failure or other chronic diseases, regular coffee consumption, pregnancy, breastfeeding, taking estrogen, progesterone, corticosteroids, weight loss supplements and obeying unusual weight loss plans

Outcomes

Primary Outcomes

intercellular adhesion molecule-1 (ICAM-1)

Time frame: 8 weeks

interleukin-6 (IL-6)

Time frame: 8 weeks

high sensitivity C-reactive protein (hs-CRP)

Time frame: 8 weeks

malondialdehyde (MDA)

Time frame: 8 weeks

Data from ClinicalTrials.gov

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