Effects of Blueberry on Gut Microbiota and Metabolic Syndrome

N/AActive Not RecruitingNCT03266055

Laval University59 enrolled

Overview

There is growing evidence that nutritional intervention with dietary polyphenols can positively modulate the gut microbiota to improve cardiometabolic health. Whether the beneficial effects of blueberries on obesity and the metabolic syndrome can be linked to their potential impact on the gut microbiota and intestinal integrity remains speculative at this time. Moreover, the mechanisms of action underlying health benefits associated to blueberry consumption are still unknown. The investigators are thus proposing to combine the study of metagenomics, transcriptomics and metabolomics to test whether a prebiotic activity of highbush blueberries can play a role in the prevention of obesity-linked metabolic syndrome in a clinical setting.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

Gut Microbiota Metabolic Syndrome

Interventions

50g of placebo blueberry powder, taken daily for 8 weeksDIETARY_SUPPLEMENT

Subjects will consume blueberry placebo powder to test if there is a significant difference on the impact on gut microbiota composition and metabolic syndrome parameters between this treatment and the active treatment (blueberry powder).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 55 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Men and premenopause women in good health * Caucasians * At least one of the following : BMI between 25 and 40 kg/m2 or Waist circumference ≥ 80 cm for women and ≥ 94 cm for men * At least one of the following : TG ≥ 1.35 mmol/L or fasting insulinemia ≥ 42 pmol/L Exclusion Criteria: * Metabolic disorders (hypertension, diabetes, hypercholesterolemia) * Regular use of medication affecting study parameters * Use of natural health product in the last 3 months * Use of antibiotics in the last 3 months * Nicotine users * Allergy or intolerance for blueberries * Blueberry taste aversion * More than 2 alcohol drinks par day * Particular dietary habits (vegetarism, gluten-free diet, cetogenic diet...) * Weight change of more than 5% in the last 3 months * Surgery in the last 3 months or planed during the study

Outcomes

Primary Outcomes

Changes in plasma insulin/glucose of overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 12 months

Changes in plasma lipids/lipoproteins of overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 12 months

Secondary Outcomes

Changes in gene expression in overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 3-6 months

Changes in metabolites concentration in overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 3-6 months

Changes in the gut microbiota composition in overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 3-6 months

Changes in blood pressure of overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 12 months

Changes in intestinal integrity of overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 12 months

Changes in inflammation biomarkers of overweight/obese men and women taking either blueberry powder or placebo blueberry powder

Time frame: 12 months

Effects of Blueberry on Gut Microbiota and Metabolic Syndrome

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes