Asparaginase Encapsulated in Erythrocytes for Patients With ALL and Hypersensitivity to PEG-asparaginase

Inclusion Criteria: 1. Male or female aged 1-45 years at diagnosis of ALL. 2. First line non-high risk ALL patients enrolled in NOPHO ALL2008 or ALLTogether pilot protocols including PEG-ASNase regimen. 3. Documented hypersensitivity reaction to PEG-ASNase with either: Clinical allergy to PEG-ASNase (mild/severe). Serum ASNase activity below the lower level of quantification. 4. Karnofsky/Lansky score ≥50. 5. Ability to understand and willingness to sign a written ICF and to comply with the scheduled visits, treatment plans, laboratory tests and other study procedures. For patients under 18 years of age, either both parents or the legally appointed representatives had to provide consent. Exclusion Criteria: 1. Philadelphia chromosome positive ALL. 2. Participation in another clinical trial interfering with the study therapy with exception of NOPHO ALL-2008 or ALLTogether pilot protocol. Patients can participate in other clinical trials not interfering with the study drug. In case of doubt this is assessed by the PI. 3. Uncontrolled intercurrent illness including, but not limited to, patients receiving combination antiretroviral therapy or patients with severe or systemic infection, or psychiatric illness/social situations that would limit compliance with study requirements. 4. Other severe acute/chronic medical or psychiatric condition or laboratory abnormality that may increase the risk associated with study participation or study drug administration, or may interfere with the interpretation of study results, and in the judgment of the investigator would make the patient inappropriate for entry into this study. 5. Pregnant or lactating females (serum human chorionic gonadotropin pregnancy test at screening). Use of a highly effective contraceptive measure in women of child-bearing potential and sexually active girls that are of child-bearing potential is required (contraceptive measures are specified in section 6.0). 6. Inadequate organ functions, which prohibit further asparaginase administration; 1. History of pancreatitis 2. History of serious hemorrhage or serious thrombosis with prior asparaginase therapy 3. Severe hepatic impairment at the time of administration (bilirubin \>3 times ULN, transaminases \>10 times ULN) 4. Pre-existing known coagulopathy (e.g. haemophilia) 7. History of grade 3 or higher transfusion reactions or any contraindication to receive blood transfusion. Presence of specific anti-erythrocytes antibodies (auto-antibodies or anti-public antibodies) preventing from getting a compatible packed Red Blood Cells for the patient. 8. Patient under concomitant treatment likely to cause hemolysis.