COGnitive ImpairmenT in Older HIV-infected Patients ≥ 65 Years Old

Fondation Ophtalmologique Adolphe de Rothschild281 enrolled

Overview

Despite combined antiretroviral therapy (cART), milder forms of HIV-associated neurocognitive disorders (HAND) persist in 20-50% of persons living with HIV (PLHIV). Since more PLH are at risk for HAND due to aging, the frequency of HAND in PLHIV ≥ 65 years old is important to quantify for planning early intervention to attenuate both functional and occupational disabilities due to cognitive impairment.

Study Type

OBSERVATIONAL

Enrollment

281

Conditions

Memory Impairment HIV/AIDS Cognitive Impairment

Interventions

assessment of cognitive impairmentOTHER

Measure of Global Deficit Score

Eligibility

Sex: ALLMin age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Personal or familial cognitive complaints * Individual aged ≥ 65 years old and \< 81 years old * Instrumental activities of daily living (IADL) score between 3-4 * French speaking individual * Informed consent signed For PLHIV * HIV infection * Undetectable HIV viral load ≥ 1 year * Current cluster of differentiation (CD4) cell count \> 100/mm3 For controls * negative HIV serology ≤ 6 months Exclusion Criteria: * Opportunistic infection \< 5 years * Contraindications to MRI

Locations (1)

Fondation Ophtalmologique A. de Rothschild /URC

Paris, France

Outcomes

Primary Outcomes

cognitive impairment

cognitive impairment frequency, defined by a z-score ≤ 1.65 in at least 2 cognitive domains

Time frame: baseline

Data from ClinicalTrials.gov

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