Efficacy of Buprenorphine on Postoperative Endodontic Analgesia

Phase 1TerminatedNCT03268278

University Hospitals Cleveland Medical Center10 enrolled

Overview

To see whether the addition of buprenorphone to local anesthesia will lengthen postoperative analgesia for endodontic pain

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Postoperative Pain

Interventions

BuprenorphineDRUG

Buprenorphine plus local anesthetic

Sterile salineDRUG

Placebo 1,8 ml

lidocaine, epinephrine (Local anesthetic)DRUG

2% lidocaine 1:100,000 epinephrine

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * persons with preoperative pain to percussion of a tooth with pulpal disease requiring endodontic therapy, healthy individuals, ASA Class I and II, no known allergies to the drugs being administered Exclusion Criteria: * pregnancy, allergy to buprenorphine, allergy to local anesthetic

Locations (1)

University Hospitals Cleveland Medical Center

Cleveland, Ohio, United States

Outcomes

Primary Outcomes

The Efficacy of Buprenorphine in addition to Local Anesthetic in Providing Prolonged Postoperative Endodontic Analgesia

The number of patients with extended postoperative analgesia when compared to the baseline in pain scores on a visual analog scale during a three-day period will be analyzed. A questionnaire containing a visual analog scale and a log for recording the use of rescue analgesics will be used to gather the data.

Time frame: two years

Data from ClinicalTrials.gov

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