Does Cefoxitin or Piperacillin-Tazobactam Prevent Postoperative Surgical Site Infections After Pancreatoduodenectomy?

Inclusion Criteria: * Age \>/= 18 years * Patients undergoing elective pancreatoduodenectomy (PD) for any diagnosis/indication Exclusion Criteria: * Patients undergoing a minimally invasive PD, such as laparoscopic or robotic PD * Patients with known and documented allergies to any of the penicillins, cephalosporins, or β-lactamase inhibitors * Patients who are otherwise ineligible to receive the antibiotics in this study * Patients highly unlikely to undergo PD according to the surgeon's judgment, such as conditions amenable to pancreas enucleation, ampullectomy, etc. * Patients with long-term glucocorticosteroid use. The following uses of corticosteroids are permitted: single doses, topical applications (e.g., for rash), inhaled sprays (e.g., for obstructive airways diseases), eye drops or local injections (e.g., intra-articular) * Patients unable to provide informed consent * Creatinine clearance (CrCl) \</= 40 mL/min * Patients receiving hemodialysis or peritoneal dialysis * Pregnant or nursing (lactating) women, where pregnancy is defined as the state of a female after conception and until the termination of gestation, confirmed by a positive hCG laboratory test * Patients with a known bacterial infection present at the time of surgery or who received antimicrobial therapy within 7 days prior to surgery