Effect of Exercise on Muscle Proteome Signature

Morten Hostrup, PhD8 enrolled

Overview

The aim of the study is to investigate skeletal muscle proteome signature changes induced by exercise training in young men

Advances in omics technologies have allowed for the identification of biomarkers with importance for the beneficial adaptations imposed by exercise training. Skeletal muscle exhibits remarkable plasticity to exercise training, as illustrated by pronounced alterations to the proteomic landscape, such as mitochondrial biogenesis. However, despite recent advances that have helped describe the proteomic landscape in response to a period of exercise training, our understanding of the processes pertaining to post-translation modification is scant. In this study, we aim to investigate the human acetylome and proteome in response to exercise training.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy

Interventions

exercise trainingOTHER

subjects complete 4-5 weeks of training

Eligibility

Sex: MALEMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * VO2max of 45-55 ml/kg/min (+/- SD) / 3000-4000 ml/min (+/- SD) * Body mass index (BMI) of 19-26 kg/m2 * Normal ECG (electrocardiography) Exclusion Criteria: * Serious adverse effects to exercise * Chronic disease

Locations (1)

Department of Nutrition, Exercise and Sports

Copenhagen, Denmark

Outcomes

Primary Outcomes

Skeletal muscle proteome signature

proteomics

Time frame: Change from baseline proteome signature at 5 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.