Description of the Functional Evolution of Diffuse Infiltrating Pneumonia Associated With Systemic Scleroderma.

University Hospital, Lille56 enrolled

Overview

Diffuse infiltrating pneumonia (DIP) is a severe complication of systemic sclerosis and one of the leading cause of death in this condition. The main objective of this study is to prospectively describe the evolution of DIP overtime and to find prognosis factors.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Systemic Sclerosis

Interventions

lung function testsOTHER

Patients hospitalized realise a Resting pulmonary function tests (PFT) which include the assessment of ventilatory capacity: spirometry (forced expiratory flows and mobilisable volumes)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 Years

Medical Language ↔ Plain English

Inclusion Criteria: * systemic sclerosis * Diffuse Infiltrating Pneumonia Exclusion Criteria: * infection * other lung diseases * non French native

Locations (2)

Hôpital Claude Huriez, CHU

Lille, France

AH-HP, Hôpital Saint Antoine

Paris, France

Outcomes

Primary Outcomes

composite criteria: forced vital capacity and CO diffusing capacity

Degradation of forced vital capacity (FVC) ≥10% and / or DLCO ≥15% of initial values at prospective follow-up at 24 months.

Time frame: At 24 months

Secondary Outcomes

composite criteria: forced vital capacity and CO diffusing capacity

Degradation of forced vital capacity (FVC) ≥10% and / or DLCO ≥15% of initial values at prospective follow-up at 12 months.

Time frame: At 12 months

Data from ClinicalTrials.gov

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