Comprehensive DNA Methylation Profiling in Crohn's Disease

Jinling Hospital, China14 enrolled

Overview

Previous studies have indicated that abnormal DNA methylation frequently occurs in the mucosa in Crohn's disease. Comprehensive DNA methylation profiling of the inflamed and non-inflamed ileal mucosa of patients with Crohn's disease was performed. Genome-wide DNA methylation was determined using the Illumina HumanMethylation 850k BeadChip.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Crohn Disease Methylation Illumina Human Methylation 850k BeadChip

Interventions

Genome-wide DNA methylationGENETIC

Genome-wide DNA methylation was determined using the Infinium Human Methylation 850K BeadChip.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Active Crohn's disease(CDAI score≥ 150) Exclusion Criteria: * No ileal lesions * Under treatment of immunomodulators, biologic agents or steroids

Locations (1)

Jinling Hospital

Nanjing, Jiangsu, China

RECRUITING

Outcomes

Primary Outcomes

Intestinal inflammation under colonoscopy

Intestinal ulcer or enteritisis observed under colonoscopy

Time frame: Jan 2017 to Sep 2017

Secondary Outcomes

CDAI

Crohns Disease Activity Index is measured.

Time frame: Jan 2017 to Sep 2017

Data from ClinicalTrials.gov

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