The Effect of Ketamine on Immune Function and Prognosis in Patients Undergoing Colorectal Cancer Resection

Yonsei University100 enrolled

Overview

Systemic inflammation caused by surgery may aggravate immunosuppression in immunocompromised cancer patients. The natural killer (NK) cell is a critical part of anti-tumor immunity. ketamine, a N-methyl-D-asparate receptor antangonist, has anti-inflammatory activity and opioid-sparing effect. This study investigate the effect of intraopertaive ketamine administration on immune function in patients undergoing laparoscopic colorectal cancer resection.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

TRIPLE

Enrollment

100

Conditions

Colorectal Cancer

Interventions

KetamineDRUG

Ketamine is administered intravenously with a loading dose of 0.25 mg/kg at 5 minutes before surgery, followed by an infusion rate of 0.05 mg/kg/h to the end of surgery.

SalineDRUG

0.9% saline solution

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient between 20 and 80 of age with ASA physical status Ⅰ-Ⅲ * patient scheduled for laparoscopic colorectal cancer resection Exclusion Criteria: * ASA physical status Ⅳ * severe hepatorenal disease * heart failure * infection * increased intracranial pressure, seizure * preoperative chemotherapy * immune or endocrine disease * metastasis to other organ * problem with communication * pregnancy * body mass index \> 35 kg/m2

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: Baseline

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: 1 hour after surgery

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: postoperative day 1

natural killer cell cytotoxicity

Natural killer cell cytotoxicity is measured with NK Vue Kit™(ATGen, Gyeonggi-do, Korea).

Time frame: postoperative day 2

Secondary Outcomes

proinflammatory cytokine

Inflammtory response is assesssed by measuring levels of proinflammtory cytokines.

Time frame: Baseline

proinflammatory cytokine

Inflammtory response is assesssed by measuring levels of proinflammtory cytokines.

Time frame: 1 hour after surgery

proinflammatory cytokine

Inflammtory response is assesssed by measuring levels of proinflammtory cytokines.

Time frame: postoperative day 1

proinflammatory cytokine

Inflammtory response is assesssed by measuring levels of proinflammtory cytokines.

Central Contacts

Jin Sun Cho, MD

CONTACT

82-2-2228-5448 chjs0214@yuhs.ac

Data from ClinicalTrials.gov

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