Safety and Immunogenicity of Concomitant Administration of EV71 Vaccine With EPI Vaccines

Inclusion Criteria: * Healthy volunteers aged 6 months * Finished two doses of vaccination (0,1 month) of hepatitis B vaccine prior to study entry * Proven legal identity * Guardian(s) of the volunteer should be capable of understanding the written consent form, and such form should be signed before the infant being included into this study Exclusion Criteria: * Finished all the three doses vaccination (0,1,6 month) of hepatitis B vaccine prior to study entry * Prior vaccination of meningococcal polysaccharide vaccine * Prior vaccination of EV71 vaccine * Unable to receive vaccination on both arms * History of hand foot and mouth disease * Previously tested HBsAg positive * Mother of the subject had been previously tested HBsAg positive * History of asthma; history of allergy to any vaccine or vaccine ingredient, or serious adverse reaction(s) to vaccination, such as urticaria, difficulty in breathing, angioneurotic edema, abdominal pain, etc * Congenital malformation, developmental disorders, genetic defects * Autoimmune disease or immunodeficiency/immunosuppressive * Severe nervous system disease or mental illness * Diagnosed coagulation function abnormal (e.g., coagulation factor deficiency, coagulation disorder, or platelet abnormalities) , or obvious bruising or coagulation disorders * Any immunosuppressant, cytotoxic medicine, or inhaled corticosteroids (except corticosteroid spray for treatment of allergic rhinitis or corticosteroid treatment on surface for acute non-complicated dermatitis) within 6 month prior to study entry * Receipt of blood product (e.g., immunoglobulin) within 3 months prior to study entry * Receipt of any other investigational medicine(s) within 30 days prior to study entry * Receipt of any live attenuated vaccine within 14 days prior to study entry * Receipt of any subunit vaccine or inactivated vaccine within 7 days prior to study entry * Acute disease or acute stage of chronic disease within 7 days prior to study entry * Axillary temperature \> 37.0 ℃ * Any other factor that suggesting the volunteer is unsuitable for this study based on the judgement of investigators Exclusion Criteria of the Second Injection: * Subjects with one of the following 1 to 3 conditions are forbidden to continue vaccination, while the other study steps could be carried out based on the judgement of investigator; for subjects with one of the following 4 to 5 conditions, whether to continue vaccination are determined by the investigator; for subjects with one of the following 6 to 7 conditions, vaccination may be delayed in the time window specified in the study: 1. Any serious adverse event that has a causal relationship with the investigated vaccine (except the group II) 2. Severe allergic reactions or hypersensitivity after vaccination (including urticaria / rash appear within 30 minutes after vaccination, except the group II ) 3. Any confirmed or suspected autoimmune disease or immunodeficiency disease (e.g., HIV infection) 4. New chronic diseases or acute stage of chronic diseases 5. Other reactions (including severe pain, severe swelling, severe activity limitation, persistent hyperthermia, severe headache or other systemic or local reactions) determined by the investigators 6. Acute diseases (moderate or severe diseases with or without fever) 7. Axillary temperature\> 37.0 ℃