The University of Hong Kong Neurocognitive Disorder Cohort

The University of Hong Kong500 enrolled

Overview

The HKU Neurocognitive Disorder (NCD) Cohort is a hospital-based, prospective, observational study of older HK Chinese adults with cognitive impairment, with a special focus on studying patients with subjective cognitive decline and mild cognitive impairment, and in particular the biomarkers that predict cognitive and functional decline. Comprehensive profiling of each subject is performed through a multi-domain assessment protocol including detailed demographics, lifestyle factors, neuropsychological battery, mood, MRI, genetics, blood biomarkers, and other patient-centred parameters including level of disability, quality of life and societal engagement. Ongoing annual follow up captures the essential clinical events and changes in neurocognitive function (conversion to MCI or dementia), mood, level of disability and quality of life; as well as repeat blood tests. The HKU NCD Cohort is the first-ever Asian dementia cohort to be formally included into the Dementia Platforms UK, achieving an international collaborative status with other UK-based cohorts. The study neuropsychological battery is aligned with the NACC UDS3 battery.

Study Type

OBSERVATIONAL

Enrollment

500

Conditions

Neurocognitive Disorder Mild Cognitive Impairment Alzheimer Dementia Vascular Dementia Age-related Cognitive Decline

Interventions

Neurocognitive batteryDIAGNOSTIC_TEST

Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted). NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.

MRIDIAGNOSTIC_TEST

MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients

Blood testsBIOLOGICAL

Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis

Eligibility

Sex: ALLMin age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Older adults with or without neurocognitive disoder. HKU NCD Cohort focuses primarily on people with Subjective Cognitive Decline (SCD) and Mild Cognitive Impairment (MCI). Exclusion Criteria: * Severe Parkinson's disease, major depressive disorder or severe psychiatric conditions, significant communication difficulties (e.g. aphasia, deafness), terminal cancer or likely end-of-life in the next 12 months.

Locations (1)

Department of Medicine, Queen Mary Hospital, The University of Hong Kong

Hong Kong, Hong Kong

RECRUITING

Outcomes

Primary Outcomes

Cognitive decline

Change in total HK-MoCA score between baseline and follow-up

Time frame: 1 year

Secondary Outcomes

Functional decline

Change in Lawton's IADL score between baseline and follow-up

Time frame: 1 year

Neuropsychiatric decline

Change in Neuropsychiatric Index (NPI) between baseline and follow-up

Time frame: 1 year

Quality of life decline

Change in QoL-AD score between baseline and follow-up

Time frame: 1 year

Change in cognitive impairment status

Progression to mild cognitive impairment (MCI) or dementia status

Time frame: 1 year

Central Contacts

Joseph SK Kwan, MD

CONTACT

+85222554769 jskkwan@hku.hk

Charlene Cheng, BA

CONTACT

+85222554769 cychar@hku.hk

Data from ClinicalTrials.gov

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