Analyzed iron status, HFE mutations and ethnicity for women in five primary care centers in the United States and Canada using de-identified data from the HEIRS study.
HEIRS included a cross-sectional screening study of 101,168 patients, 25 years of age or older, in the primary care setting. Participants were recruited from four centers in the U.S .and one in Canada from February 2001 to February 2003. We will evaluate results for women aged 25-44 years of age who are self-reported as Asian, Black, Hispanic or White. The lower detection limit for the serum ferritin (SF) assay in the HEIRS study was 15 μg/L and therefore the definition of iron deficiency will be SF concentration ≤ 15 μg/L. Elevated SF concentrations, possibly indicative of elevated iron stores, will be classified by two definitions: 1) SF concentration \> 300 μg/L and 2) SF \>200 μg/L in combination with TSAT \>45%. Proportions will be compared by Pearson's chi-square. Logistic regression models will be used to identify independent associations with measures of iron deficiency and elevated iron stores.
Study Type
OBSERVATIONAL
Enrollment
22,042
observation
University of Illinois at Chicago
Chicago, Illinois, United States
Elevated serum ferritin
Serum ferritin \>300 ug/L
Time frame: One measurement was made at the time of recruitment and this is the measurement that will be analyzed.
Elevated serum ferritin and transferrin saturation
Serum ferritin \>200 ug/L and transferrin saturation \>45%
Time frame: One measurement was made at the time of recruitment and this is the measurement that will be analyzed.
Iron deficiency
Serum ferritin \<15ug/L
Time frame: One measurement was made at the time of recruitment and this is the measurement that will be analyzed.
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