Single and Multiple-Ascending Dose Study of CRN00808 in Healthy Volunteers

Inclusion Criteria: * BMI 18 to 30 kg/m2 * Females postmenopausal or surgically sterile Exclusion Criteria: * Any uncontrolled or active major systemic disease including, but not limited to: acromegaly (with or without pituitary surgery or radiation therapy), cardiac, pulmonary, gastrointestinal, metabolic, urogenital, neurological, immunological, psychiatric, or neoplastic disorder with metastatic potential * History or presence of malignancy within the past 5 years. Subjects who have been successfully treated (for 3 months or longer) with no recurrence of basal or squamous cell carcinoma of the skin or carcinoma in-situ of the cervix may be enrolled. * Use of any investigational drug within the past 60 days or 5 half-lives, whichever is longer * Have a medically significant abnormality observed during screening or the admission physical examination or in any other baseline measurements * Use of any prior medication without approval of the investigator within 14 days prior to admission * Tested positive at screening for HIV, hepatitis B surface antigen (HBsAg) or hepatitis C antibody (HCV-Ab) or has a history of a positive result * History of alcohol or substance abuse in the past 6 months * Any condition that in the opinion of the investigator would jeopardize the subject's appropriate participation in this Phase 1 study