The proposed research evaluates tissue oxygenation (StO2) as measured by resonance raman spectroscopy (RRS) in premature infants with and without patent ductus arteriosus (PDA). This is a prospective observational study of infants born at \< 30 weeks of gestation. The primary aim of this study is to determine if the difference in pre- and post-ductal StO2 as detected by RRS is more significant in premature infants with PDA in comparison to infants without PDA. The secondary aim of this study is to determine if the difference in pre- and post-ductal StO2 as detected by RRS is more significant in infant who develop serious adverse events.
Study Type
OBSERVATIONAL
Enrollment
55
Pre and post-ductal RRS measurements will be obtained daily for a maximum of 14 data collection times in infants with and without PDAs.
University of Florida
Gainesville, Florida, United States
Boston Children's Hospital
Boston, Massachusetts, United States
Differences and pre- and post-ductal RRS measurements of tissue oxygenation.
Pre- and post-ductal tissues oxygenation as measured by RRS may be more significant in infants with PDA.
Time frame: Up to a maximum of 14 data collection times
Are differences in pre- and post-ductal StO2 as detected by RRS more significant in infants with serious adverse events.
RRS measurements and the difference between pre- and post-ductal tissue oxygenation will be evaluated in infants with serious adverse events to determine if the measurements could have predicted the serious adverse event.
Time frame: Up to a maximum of 14 data collection times
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