Ramosetron is commonly used to prevent postoperative nausea and vomiting (PONV) in the Eastern Asia. The prolongation of QTc interval is a main side effect. In this study, the pre-treatment time of ramosetron to decrease PONV, and QTc prolongation is compared.
This prospective study evaluate 42 female patients who underwent laparoscopic gynecologic surgery under general anesthesia. Group I (n=21) receive 0.6mg of ramosetron at anesthesia induction. Group R (n=21) received the same at the end of surgery. PONV is evaluated at arrival to post-anesthetic care unit (PACU), before induction, discharge from PACU, 24-, 48-, and 72- after discharge from PACU. The QTc interval is checked before anesthesia, at arrival to PACU, and 24-h after discharge from PACU. Forty two subjects are needed with an α value of 0.05, a power of 0.8, and effect size difference of 0.9.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
64
Intravenous ramosetron 0.6mg is given to the patients at the induction of anesthesia, or at the end of surgery
Lee Sung Ho
Seoul, South Korea
QTc interval change
Difference of QTc interval from preoperative value
Time frame: within 10 min after arrival at PACU, and 24 hour after discharge from PACU
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