Adolescent Master Protocol for Participants 18 Years of Age or Older - Lite

Harvard School of Public Health (HSPH)334 enrolled

Overview

This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection as they transition to adulthood.

This is a prospective cohort study designed to define the impact of HIV infection and antiretroviral therapy (ART) on young adults with perinatal HIV infection as they transition to adulthood. The primary objectives of this study are: 1. To identify infectious and non-infectious complications of HIV disease and toxicities resulting from long-term ART, including disease progression, immune suppression, viral resistance, end-organ disease, and mortality. 2. To define the impact of HIV infection and ART on the long-term clinical outcomes of young adults with perinatal HIV. 3. To define the impact of perinatal HIV infection and ART on long-term mental and behavioral health outcomes.

Study Type

OBSERVATIONAL

Enrollment

334

Conditions

HIV/AIDS

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Perinatal HIV infection as documented in the medical record; * At or beyond their 18th birthday at the time of informed consent with no upper age limit; * Willingness to provide access to existing medical records; and * Willingness to participate and provide legal consent Exclusion Criteria: * Prisoner status

Locations (9)

University of Southern California

Los Angeles, California, United States

David Geffen School of Medicine at UCLA

Los Angeles, California, United States

Emory University School of Medicine

Atlanta, Georgia, United States

Outcomes

Primary Outcomes

HIV Disease Progression

Factors of interest for this outcome include virologic suppression, immune impairment, immune activation, changes in ART, cumulative exposure to specific ART, viral resistance, co-infections, and host genetic polymorphisms. Data will be collected through chart abstraction.