Metals and oxydes are found in welding fumes and are thought to participate in increasing cardiovascular risk in exposed workers. Investigators aimed to evaluate the impact of this occupational exposure on cardiovascular system in a highly exposed population, ship repairing welders and to compare this population to paired controls.
In an exposed-non-exposed study, investigators will include 30 welders and 30 airport runway agents for control. As part of cardiovascular independent risk factors, microvascular endothelial function will be evaluated directly by laser Doppler flowmetry. Blood samples will be also collected and circulating markers of endothelial function (VW factor, E-selectin, VCAM, ICAM, circulating DNA), inflammation (CRP, IL-1β, IL-8, TNFα, IL-10), platelet activation (procoagulant microparticles, thrombin generation, fibin monomer) will be measured. A complete clinical and functional cardiovascular status will be documented in every participant.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
51
Diagnostic tests : * laser doppler * blood tests * Holter ECG. No drug and no placebo were used in this arm.
CHRU Brest
Brest, France
Vascular reactivity
Assessement of microvascular reactivity by laser Doppler flowmetry associated to iontophoretic administration of ACh and SNP
Time frame: 1 day
Coagulation activation
Assessment of markers of blood coagulation
Time frame: 1 day
vascular inflammation
Assessment of factors of inflammation
Time frame: 1 day
Impregnation of metals activation
Assessment of impregnation factor
Time frame: 1 day
Oxidative stress activation
Assessment of markers of oxidative stress
Time frame: 1 day
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