A Prospective Study of Evaluation of Minor Bleeding and Utility of Bleeding Criteria in Acute-on-chronic Liver Failure Patients in China

Nanfang Hospital, Southern Medical University100 enrolled

Overview

Ineffective hemostasis or a paradoxical prothrombotic state of Acute-on-chronic liver disease (ACLF) has been well established. However, the minor and major bleeding events has not been described yet. We observe the patients' major and minor bleeding events and use 4 criteria, which include BARC, ISTH, TIMI, Gusto ,to evaluate the incident rate of bleeding events in ACLF patients and pre-ACLF patients.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Liver Failure, Acute on Chronic Hemostatic Disorder

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient with previously or undiagnosed chronic liver disease/cirrhosis; * serum bilirubin higher than 3 mg/dl (51 mmol/L) or ALT\>10ULN（male 300 U/L; female 200 U/L) Exclusion Criteria: * those who had or been diagnosed hepatocellular carcinoma or other types of malignancies; * pregnancy; * obstructive biliary diseases or other disease lead to bilirubin evaluation; * using steroid or immunosuppressant in 4 weeks; * prior surgeries including splenectomy，subtotal splenectomy and disconnection，liver transplantation. * combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8)

Locations (1)

Outcomes

Primary Outcomes

28-day progression

progressed to EASL or APASL defined ACLF or death

Time frame: 28-day

Secondary Outcomes

major bleeding event

major bleeding event happen

Time frame: 90-day

28-day mortality

death within 28 days