A Prospective Study of Application of Platelet Mapping in HBV-related Acute-on-chronic-liver Failure in China

Inclusion Criteria: * patient with previously diagnosed or undiagnosed HBV related chronic liver disease/cirrhosis * INR≥1.5 and total bilirubin≥85μmol/L Exclusion Criteria: * INR≤1.5 or total bilirubin≤85μmol/L; * underlying chronic liver disease was other than chronic HBV infection related; * those who had hepatocellular carcinoma or other types of malignancies; * obstructive biliary diseases or other disease lead to bilirubin evaluation; * those who had acute hemorrhage one week before admission * those who received platelet, cryo transfusion or plasmapheresis one week before admission * using steroid or immunosuppressant or antiplatelet or anticoagulant drugs in 4 weeks * any kind of decompensation which persisted over a month * pregnancy and breastfeeding * those who received liver transplantation or kidney transplantation; * combine with other disease lead to organ failure including heart failure (NYHA IV),respiratory failure（PaO2\<60mmHg),renal insufficiency(CKD 5) and conscious disturbance (GCS\<8) * readmission; * death within 24 hours.