Comparison of Positive End Expiratory Pressure Titration Methods in ARDS Patients

University Hospital, Angers20 enrolled

Overview

This study aims at assessing the short-term physiological effects of 2 positive end expiratory pressure titration strategies in patients with ARDS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Acute Respiratory Distress Syndrome

Interventions

Strategy 1OTHER

PEEP titration according to transpulmonary-end-expiratory pressure

Strategy 2OTHER

PEEP titration according to chest wall elastance measurement

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age\> 18 years * Moderate or severe ARDS * Consent to participation obtained from a relative Exclusion Criteria: * Protect adult * Pregnant or breastfeeding woman * No-affiliation to the social security scheme * Contra-indication to the placement of an esophageal pressure measuring catheter * Pneumothorax * Hemodynamic and / or respiratory instability * Extra-corporeal membrane oxygenation

Locations (1)

University Hospital

Angers, France

RECRUITING

Outcomes

Primary Outcomes

Short-term effects of 2 PEEP titration strategies on gas exchange

Time frame: 2 hours 15 minutes

Secondary Outcomes

Short-term effects of 2 PEEP titration strategies on respiratory mechanics

Time frame: 2 hours 15 min

Short-term effects of 2 PEEP titration strategies on hemodynamics

Time frame: 2 hours 15 min

Central Contacts

Study Official is required by the WHO and BELONCLE, Ass.Pr

CONTACT

0241353845 Francois.Beloncle@chu-angers.fr

Data from ClinicalTrials.gov

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