Elevated Stearoyl-CoA Desaturase-1 Expression Predicts the Disease Severity of Severe Acute Pancreatitis

Nanjing University School of Medicine216 enrolled

Overview

In this study, the investgatiors aimed to investigate the associations between serum levels of stearoyl-CoA desaturase-1（SCD-1） and the disease severity as well as the presence of adverse clinical events, such as local complications, organ failure, mortality and so on.In this prospective study, participants were divided into two groups based on serum SCD-1 concentration on admission and prospectively observe the disease severity and clinical outcomes of them.

Study Type

OBSERVATIONAL

Enrollment

216

Conditions

Acute Pancreatitis Organ Failure, Multiple

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Diagnosis of acute pancreatitis (Atlanta standard), abdominal pain occurred within one week of admission; 2. APACHEII score is more than 8 and Ranson score is greater than 3; 3. Age 18-75; 4. Obtaining informed consent. Exclusion Criteria: 1. Pregnancy pancreatitis; 2. Patients with the following disease history: severe cardiac, pulmonary, renal, liver function insufficiency or immunodeficiency disease.

Outcomes

Primary Outcomes

the incidence rate of infected pancreatic necrosis

Time frame: 2-4 week after disease onset

Secondary Outcomes

the incidence rate of organ failure

the incidence rate of organ failure (transient or persistent)

Time frame: 1-2 week after disease onset

the incidence rate of local complications

acute peripancreatic fluid collections, pancreatic pseudocycts, acute necrotic collections and walled-off necrosis

Time frame: 1-2 week after disease onset

Data from ClinicalTrials.gov

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