Safety Study of Human Neural Stem Cells Injections for Secondary Progressive Multiple Sclerosis Patients

Inclusion Criteria: 1. SPMS with progressive accumulation of disability after initial relapsing course, with or without disease activity (Lublin et al. 2014). 2. EDSS ≥ 6.5 and ≤ 8 3. EDSS progression over the 2 years prior to study start of ≥ 1.0 point for patients with EDSS =6.5 at the time of inclusion , and of ≥ 0.5 points for patients with EDSS \> 6.5 at the time of inclusion 4. Age ≥ 18 and ≤ 60 years 5. Failure of best medical treatment as judged by the treating neurologist and declared absence of therapeutic alternatives Exclusion Criteria: 1. Neurological conditions other than MS. 2. Psychiatric disorders, severe cognitive decline and personality and relational disorders. 3. History or known presence of significant systemic, infectious, oncologic or metabolic disorders. 4. Presence of any other autoimmune disease. 5. Chronic infections (HBV, HCV, HIV, tuberculosis). 6. Inability to perform MRI scans. 7. Immunomodulant/immunosuppressive treatments in the last 6 months before inclusion. 8. Current participation to other experimental studies. 9. Inability to provide informed consent. 10. Any contra-indication to lumbar puncture and the surgical procedure (e.g. use of anticoagulants) 11. Pregnancy and breast feeding.