Exposure to acute intermittent hypoxia (AIH) can facilitate of motor output but no studies of sensory effects has been reported.
Despite the strong results of motor studies, the affects of AIH on sensory function has not been established. We will use a commercially-available hypoxicator that can be programmed to achieve a targeted level of arterial oxygen saturation. We plan to compare 3 previously published protocols that have generated motor facilitation (and a sham condition) to characterize and effects on sensory function in healthy adults.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
22
15 bouts of 2mins:1min hypoxia:hyperoxia
15 bouts of 1mins:1min hypoxia:hyperoxia
8 bouts of 2mins:1min hypoxia:hyperoxia
Unversity of Florida
Gainesville, Florida, United States
Sensory Function
Thermal thresholds. Average reported.
Time frame: Every 10 minutes for 60 minutes post intervention, average reported
Temporal Sensory Summation
Temporal summation represents increases in ratings of pain intensity measured using a numeric pain rating scale (0-no pain to 100-worst pain imaginable) to repeated heat stimuli of the same intensity; that is, "summation" represents increases in participant ratings of pain despite the maintenance of a standard temperature and is calculated as the difference between pain rating 1 and pain rating 6. Positive difference scores indicate that pain reported increased over the 6 pulses of heat. Here, the average difference across participants and over time is reported.
Time frame: Every 10 minutes for 60 minutes post intervention, average reported
Sensory Function - Pressure
Pressure threshold is the force at which the sensation of pressure first is considered painful by the participant, average reported
Time frame: Every 10 minutes for 60 minutes post intervention, average reported
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15 bouts of 1min:1min normoxia