Comparing Transvaginal Self-tailored Titanium-coated Polypropylene Mesh Procedure With Mesh-kit Procedure.

Inclusion Criteria: * Age:More than 50 years old with 3 years after menopause or more than 55 years old, but less than 75 years old. * Subject must have severe apical or anterior vaginal prolapse (stage III-IV), with moderate posterior vaginal prolapse(stage I-II). This is defined as ( C \> +1cm OR Ba \> +1cm, with Bp ≤+1cm by the POP-Q). This is the most common modality of multiple compartment POP in clinic. * Subject reports a bothersome bulge they can see or feel per PFDI-20, question 3, response of 2 or higher (i.e., responses of "somewhat", "moderately", or "quite a bit"). * Desires transvaginal mesh treatment for primary or recurrent, symptomatic uterovaginal prolapse. * Concomitant hysterectomy when indicated. But concomitant anti-incontinence surgeries will not be enrolled. * Subject is willing and able to comply with the follow-up regimen. Exclusion Criteria: * Subject is pregnant or intends to become pregnant in the future * Subject has an active or chronic systemic infection including any gynecologic infection, untreated urinary tract infection (UTI) or tissue necrosis * Subject has history of pelvic organ cancer (e.g. uterine, ovarian, bladder, colo-rectal or cervical) * Subject has had prior or is currently undergoing radiation, laser therapy, or chemotherapy in the pelvic area * Subject has taken systemic steroids (within the last month), or immunosuppressive or immunomodulatory treatment (within the last 3 months) * Subject has systemic connective tissue disease (e.g. scleroderma, systemic lupus erythematosus (SLE), Marfan syndrome, Ehlers Danlos, collagenosis, polymyositis, polymyalgia rheumatica) * Subject has chronic systemic pain that includes the pelvic area or chronic focal pain that involves the pelvis * Subject has uncontrolled diabetes mellitus (DM) * Subject has a known neurologic or medical condition affecting bladder function (e.g., multiple sclerosis, spinal cord injury or stroke with residual neurologic deficit) * Subject has had previous prolapse repair with mesh in the target compartment