Determination of Propofol Target Concentration for Young and Elderly by Suppression Rate Analysis

Brasilia University Hospital

Overview

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Adaptative clinical trial (Dixon's Up and Down) for determination of ED95% of propofol concentration for hypnosis under general anesthesia for young and elderly adults.

Propofol's dose-response curve is know for the average adult but propofol's plasmatic concentration under total intravenous anesthesia differences between young and elderly must be modeled. Method: adaptative clinical trial (Dixon's Up and Down method) for determination of ED95% of propofol concentration (plasmatic, Marsh model) for hypnosis (BIS ranging from 40 to 60) under general anesthesia for young and elderly adults.

Study Type

INTERVENTIONAL

Allocation

Purpose

SUPPORTIVE_CARE

Masking

NONE

Conditions

Anesthesia

Interventions

PropofolDRUG

Propofol plasmatic concentration (Marsh)

Eligibility

Sex: ALLMin age: 18 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Both sex * Between 18-28 or 65-75 years old * ASA physical status I or II * no pre-anesthetic medications prescribed * scheduled for surgery under general anesthesia * willing to participate and sign informed consent. Exclusion Criteria: * Contraindications for propofol usage * history of neurologic or psychiatric diseases * drug abusers * users of drugs that alter central nervous system * pregnancy * emergency surgeries * rapid sequence intubation.

Outcomes

Primary Outcomes

BIS value greater than 60 or lower than 40 during general anesthesia

Time frame: BIS value greater than 60 or lower than 40 during general anesthesia

Data from ClinicalTrials.gov

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