Focused stereotactic radiation treatment of localized prostatic adenocarcinoma. in order to quantify the delay between the focused treatment and the salvage procedure.
Focused stereotactic radiation treatment of localized prostatic adenocarcinoma. in order to quantify the delay between the focused treatment and the salvage procedure. Second objectives : objectives: prostate-specific antigen (PSA) response, MRI response, toxicity (CTCAEv4), quality of life (International Prostate Symptom Score (IPSS) and The International Index of Erectile Function (IIEF5) scores). Method At first: Multiparametric Magnetic resonance imaging (MRI) - 12 biopsies within the whole gland. Placement under endorectal ultrasound control of 4 fiducials at least 2 cm spaced. Treatment : CyberKnife radiation treatment delivering 36.25 Gy in 5 fractions, in 10 days. Tracking using the 4 fiducials. Critical organs: Rectal and bladder wall: V35\<2cc. Bladder neck and urethra: V35\<1cc. Salvage treatments: in such a context, salvage surgery or salvage intensity modulation radiation therapy (IMRT) treatments can in theory remain valid and safe options.
Study Type
OBSERVATIONAL
Enrollment
26
Centre Francois Baclesse
Esch-sur-Alzette, Luxembourg
Delay between the initial diagnosis and date of salvage treatment
Delay between the initial diagnosis and date of salvage treatment
Time frame: through study completion, up to 36 months
PSA evaluation
PSA dosage
Time frame: 3, 6, 12, 18, 24, 30, 36 months
Birads score evaluation
Multiparametric prostatic MRI
Time frame: 12, 24, 36 months
Acute and late toxicity
Acute and late toxicity using the CTCAEv4
Time frame: 3, 6, 12, 18, 24, 30, 36 months
IPSS evaluation
IPSS score
Time frame: 12, 24, 36 months
IIEF5 evaluation
IIEF5 score
Time frame: 12, 24, 36 months
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