Does Placenta Pathology Predict Outcome of Neonates With Hypoxic Ischemic Encephalopathy?"

University Children's Hospital, Zurich100 enrolled

Overview

The histology of the placenta of newborn infants with perinatal asphyxia and hypoxic-ischaemic encephalopathy is analysed. There will be an evaluation if placenta could be a biomarker for neurodevelopmental outcome at 18-24 months of age.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Asphyxia Neonatorum

Interventions

hypothermia therapyOTHER

newborn infants with hypoxic-ischaemic encephalopathy are cooled for 72 hours with a target temperature of 33-34°C (whole body cooling).

Eligibility

Sex: ALLMin age: 1 DayMax age: 4 Days

Medical Language ↔ Plain English

Inclusion Criteria:all newborn infants with APGAR \<5 at 10minutes, pH\<7.0, lactate \>12mmol/L, base excess \>16, resuscitation \>10min after birth, gestational age \>35 weeks and an encephalopathy - Exclusion Criteria: \-

Locations (1)

University Children's hospital Zurich

Zurich, Switzerland

Outcomes

Primary Outcomes

neurodevelopmental outcome at 18-24 month of Age

The investigators will analyse if there is a correlation of placenta histology and neurodevelopmental outcome

Time frame: 7 years

Data from ClinicalTrials.gov

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