The purpose is to show that bifocal tDCS with an anodal stimulation on the orbitofrontal cortex and cathodic stimulation on supplementary motor areas is an effective treatment for patients with resistant and severe obsessive compulsive disorders.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
Patients will receive an active Treatment with tDCS (10 sessions of 30 mn with an intensity of 2 mA)
Centre Hospitalier Henri Laborit
Poitiers, France
The primary outcome measure is used to show that bifocal tDCS with anodal stimulation on OFC and cathodic stimulation on the SMA is an effective treatment
Score improvement on the Y-BOCS after 14 days compared to the baseline
Time frame: Day 14
Evaluate the persistence of therapeutic response at 45 days
Score improvement on the Y-BOCS after 45 days compared to the baseline
Time frame: Day 45
Evaluate the persistence of therapeutic response at 105 days
Score improvement on the Y-BOCS after 105 days compared to the baseline
Time frame: Day 105
Evaluate the therapeutic effect of tDCS on the depressive and anxious symptoms associated with Obsessive compulsive disorder at 14 days
Score improvement of Hamilton and HDRS scales between the baseline and day 14
Time frame: Day 14
Evaluate the therapeutic effect of tDCS on the depressive and anxious symptoms associated with Obsessive compulsive disorder at 45 days
Score improvement of Hamilton and HDRS scales between the baseline and day 45
Time frame: Day 45
Evaluate the therapeutic effect of tDCS on the depressive and anxious symptoms associated with Obsessive compulsive disorder at 105 days
Score improvement of Hamilton and HDRS scales between the baseline and day 105
Time frame: Day 105
Evaluate the effect of tDCS on the quality of life at day 14
Improvement of MOS SF-36 scale (Medical Outcome Study, Short Form) between baseline and day 14
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Time frame: Day 14
Evaluate the effect of tDCS on the quality of life at day 45
Improvement of MOS SF-36 scale (Medical Outcome Study, Short Form) between baseline and day 45
Time frame: Day 45
Evaluate the effect of tDCS on global functioning at day 14
Improvement of GAF (Global Assessment of Functioning) scale between baseline and day 14
Time frame: Day 14
Evaluate the effect of tDCS on global functioning at day 45
Improvement of GAF (Global Assessment of Functioning) scale between baseline and day 45
Time frame: Day 45
Evaluate the effect of tDCS on social adjustment at day 14
Improvement of SAS (Social Adjustment Scale) scale between baseline and day 14
Time frame: Day 14
Evaluate the effect of tDCS on social adjustement at day 45
Improvement of SAS (Social Adjustment Scale) scale between baseline and day 45
Time frame: Day 45