Treatment Plan for an Individual Patient With Recurrent Uterine Papillary Serous Carcinoma (UPSC) With PIK3CA Gene Mutation

Inclusion Criteria: 1. Patient has adequate bone marrow and coagulation function as shown by: absolute neutrophil count (ANC) ≥ 1.5 × 109/L; platelets ≥ 100 × 109/L; hemoglobin (Hgb) ≥ 9.0 g/dL. 2. Patient has adequate liver function as shown by: 1. total serum bilirubin ≤2.0 mg/dL, 2. ALT and AST ≤2.5x ULN (≤5x ULN in patients with liver metastases), 3. INR ≤2;. 3. Patient has adequate renal function as shown by serum creatinine ≤ 1.5 × ULN. 4. Patient has fasting serum cholesterol ≤ 300mg/dl or 7.75mmol/L AND fasting triglycerides ≤ 2.5 × ULN. NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication. 5. Patient will give a written informed consent obtained according to local guidelines. 6. Sexually active males must use a condom during intercourse while taking everolimus for treatment, for 8 weeks after stopping treatment, or their female partners should use highly effective contraception during this specified time period. 7. Women of childbearing potential must have had a negative serum pregnancy test 14 days prior to the start of everolimus treatment plus a negative local urine pregnancy test prior to treatment and must be willing to use highly effective methods of contraception during the study and for 8 weeks after study drug administration. Exclusion Criteria: 1. Patient has had prior therapy with mTOR inhibitors (e.g. sirolimus, temsirolimus, deforolimus). 2. Patient has a known intolerance or hypersensitivity to everolimus or other rapamycin analogs (e.g. sirolimus, temsirolimus). 3. Patient has uncontrolled diabetes mellitus as defined by fasting serum glucose \> 1.5 × ULN despite adequate therapy. Patients with a known history of impaired fasting glucose or diabetes mellitus (DM) may be included, however blood glucose and antidiabetic treatment must be monitored closely throughout participation in the program and adjusted as necessary. 4. Patient has any severe and/or uncontrolled medical conditions such as: 1. unstable angina pectoris, symptomatic congestive heart failure, myocardial infarction ≤6 months prior to randomization, serious uncontrolled cardiac arrhythmia, 2. active or uncontrolled severe infection, 3. liver disease such as cirrhosis, decompensated liver disease, and chronic hepatitis (i.e. quantifiable HBV-DNA and/or positive HbsAg, quantifiable HCV-RNA), 4. known severely impaired lung function (spirometry and DLCO 50% or less of normal and O2 saturation 88% or less at rest on room air), 5. active, bleeding diathesis. 5. Chronic treatment with corticosteroids or other immunosuppressive agents. 6. Patient has a known history of HIV seropositivity. 7. Patient is a woman of child-bearing potential, unless she is using highly effective contraception methods. * Women of child-bearing potential (WOCBP) is defined as all women physiologically capable of becoming pregnant, including women whose career, lifestyle, or sexual orientation precludes intercourse with a male partner and women whose partner has been sterilized by vasectomy or other means. * Highly effective contraception, defined as one that results in an annual pregnancy rate \<1% when used correctly, comprises one of the following methods: * Total abstinence (when this is in line with the preferred and usual lifestyle of the subject. Periodic abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods) and withdrawal are not acceptable methods of contraception) * Male/female sterilization * Use of oral, injected or implanted hormonal methods of contraception or placement of an intrauterine device (IUD) or intrauterine system (IUS) or other forms of hormonal contraception that have comparable efficacy (failure rate \<1%), for example hormone vaginal ring or transdermal hormone contraception 8. Patient is unwilling to or unable to comply with the treatment plan.