Longitudinal, observational study to assess the short-term (test re-test) and mid-term (within the span of 28 days) repeatability of active anterior rhinomanometry (AAR) measures on 4 parallel groups of children with different rhinitis phenotypes, and 1 group of control (healthy) children. Secondary objectives are: i) assessing of association between AAR, exhaled FeNO (eFeNO) and nasal FeNO (nFeNO); ii) assessing association between objective measurements (AAR, eFeNO and nFeNO) and subjective measurements (Total 5 Symptom score, T5SS). The study is intended to obtain useful information for improving rhinitis management.
Study Type
OBSERVATIONAL
Enrollment
50
Institute of Biomedicine and Molecular Immunology (IBIM), National Research Council
Palermo, Sicily, Italy
Short term repeatability of active anterior rhinomanometry (AAR)
For each individual, it will be calculated the coefficient of variation of 5 measurements of AAR taken within 30 minutes, at baseline.
Time frame: 1 day
Mid term repeatability of active anterior rhinomanometry (AAR)
For each individual, it will be calculated the coefficient of variation of 3 measurements of AAR taken at baseline and then twice more within the span of 28 days (after one week and after two weeks).
Time frame: 28 days
Correlation between AAR and oral FeNO
Correlation coefficients between measurements of AAR and oral FeNO (at each visit the mean of 3 consecutive measurements of oral FeNO is considered)
Time frame: 28 days
Correlation between AAR and nasal FeNO
Correlation coefficients between measurements of AAR and nasal FeNO (at each visit the mean of 3 consecutive measurements of nasal FeNO is considered)
Time frame: 28 days
Correlation between AAR (objective perspective) and T5SS (subjective perspective)
Correlation coefficients between measurements of AAR and total 5 symptom score
Time frame: 28 days
Correlation between FeNO (objective perspective) and T5SS (subjective perspective)
Correlation coefficients between measurements of FeNO and total 5 symptom score
Time frame: 28 days
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