Use of Peppermint Oil During Screening Colonoscopy to Improve Visibility

Mayo Clinic48 enrolled

Overview

The investigators hypothesize that spraying peppermint oil containing L-menthol onto the colonic mucosa during colonoscopy will relax smooth muscle allowing better colonic visualization.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

DIAGNOSTIC

Masking

TRIPLE

Enrollment

Conditions

Enhancement of the ADR During Colonoscopy

Interventions

Peppermint OilOTHER

Distilled waterOTHER

Distilled water spray as a placebo during Colonoscopy

Eligibility

Sex: ALLMin age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Screening colonoscopy * Age 50 years and older * Able to give consent Exclusion Criteria: * No consent obtained or adult lacking capacity to consent * Do not reach cecum on colonoscopy * Renal impairment (defined as CrCl \<30 ml/min) * Allergy to study peppermint oil solution * History of colon resection * Inflammatory bowel disease * Known colorectal neoplasia * Non-correctable coagulopathy * Pregnancy or lactating * Prisoners

Locations (1)

Mayo Clinic in Arizona

Scottsdale, Arizona, United States

Outcomes

Primary Outcomes

Determination of Adenoma Detection Rate during Colonoscopy Procedure

Time frame: 2 hours

Data from ClinicalTrials.gov

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