The purpose of this study is to evaluate this new technology available at the University of Wisconsin Carbone Cancer Center in the setting of head and neck cancer radiation treatment planning. This study will also provide preliminary data critical to the development of multi-parametric, multi-modality quantitative imaging biomarkers and data analysis models for prediction of outcome in both tumors and normal tissue, which are essential for patient-specific adaptive therapy. All participants will undergo a diagnostic PET/CT and a Radiation Treatment Planning CT per SOC procedures. In addition, all participants will undergo an additional imaging set consisting of a PET/MRI. It is anticipated that most patients will undergo the PET/MRI on the same day as their PET/CT negating the need for a second injection of the FDG radioisotope used for SOC PET imaging. All patients will receive gadolinium contrast per SOC dosing guidelines for the MRI portion of the PET/MRI. Both SOC MMRI pulse sequences and investigational sequences will be utilized in this study.
Study Type
OBSERVATIONAL
Enrollment
3
Participants will be placed in standard non-ferrous head and neck immobilization devices during PET/MRI (to simulate their anticipated positioning during subsequent CT simulation and treatment). A head/neck PET/MRI (standard bore size, 60 cm) will be performed
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, United States
Percentage of participants able to complete the PET/MRI examination
Identify the percentage of head and neck cancer patients who are able to successfully complete or partially complete the PET/MRI examination. Responses to a 7 point Likert scale will be analyzed with a chi-squared test.
Time frame: Up to 1 year
Changes in staging between PET/CT and PET/MRI
Compare changes in tumor and regional staging between PET/CT and PET/MRI. Responses to a 7 point Likert scale will be analyzed with a chi-squared test.
Time frame: Up to 1 year
Feasibility of PET/MRI in radiation treatment planning workflow
Assess the feasibility of PET/MRI in the radiation treatment planning workflow with respect to the adequacy of image quality and image fusion of PET/MRI data with the treatment planning CT, as compared to PET/CT.
Time frame: Up to 1 year
Compare conventional MRI pulse sequences to investigational MRI pulse sequences for tumor conspicuity and image quality
Pulse sequences will be assess with Wilcoxon signed rank test.
Time frame: Up to 1 year
Compare changes in simulated radiation treatment volume when derived from PET/MRI vs PET/CT (GTV, CTV, PTV)
Differences in simulated radiation treatment planning volumes will be assess with Wilcoxon signed rank test.
Time frame: Up to 1 year
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