EVOlocumab for Early Reduction of LDL-cholesterol Levels in Patients With Acute Coronary Syndromes (EVOPACS)

Inclusion Criteria: Male or female ≥ 18 years of age; * Hospitalized for a recent ACS; * LDL-C levels defined as follows: * LDL-C ≥70 mg/dL (≥1.8 mmol/L) or non-HDL-C ≥100 mg/dL (≥2.6 mmol/) in patients who have been receiving stable treatment with high-intensity statin within ≥ 4 weeks prior to enrollment (i.e. continuous treatment that has not changed with regard to statin intensity over the past 4 weeks) or, LDL-C ≥90 mg/dL (≥2.3 mmol/L) or non-HDL-C ≥120 mg/dL (≥3.1 mmol/) in patients who have been receiving stable treatment with low- or moderate-intensity statin within ≥ 4 weeks prior to enrollment (i.e. continuous treatment that has not changed with regard to statin intensity over the past 4 weeks), or LDL-C ≥125 mg/dL (≥3.2 mmol/L) or non-HDL-C ≥155 mg/dL (≥4.0 mmol/) in patients who are statin-naïve or have not been on a stable (unchanged) statin regimen for at least 4 weeks prior to enrollment; * Ability to understand the requirements of the study and to provide informed consent. Exclusion Criteria: * Unstable clinical status (hemodynamic or electrical instability; * Uncontrolled cardiac arrhythmia, defined as recurrent and symptomatic ventricular tachycardia or atrial fibrillation with rapid ventricular response not controlled by medications in the past 3 months prior to screening; * Severe renal dysfunction, defined by estimated glomerular filtration rate \<30 ml/min/1.73m2; * Active liver disease or hepatic dysfunction, either reported in patient medical record or defined by asparate aminotransferase (AST) or alanine aminotransferase (ALT) levels \> 3x the upper limit of normal; * Reported intolerance to atorvastatin (any dose) OR statin intolerance; * Known allergy to contrast medium, heparin, aspirin, ticagrelor or prasugrel; * Known sensitivity to any substances to be administered; * Patients who previously received evolocumab or other PCSK9 inhibitor; * Patient who received cholesterol ester transfer protein inhibitors in the past 12 months prior to screening; * Treatment with systemic steroids or systemic cyclosporine in the past 3 months systemic cyclosporine, systemic steroids (eg. intravenous, intramuscular or per os); * Known active infection or major hematologic, metabolic, or endocrine dysfunction in the judgment of the Investigator; * Patients who will not be available for study-required procedures in the judgment of the Investigator; * Current enrollment in another investigational device or drug study; * Active malignancy requiring treatment; * Female of childbearing potential (age \<50 years and last menstruation within the last 12 months), who did not undergo tubal ligation, ovariectomy or hysterectomy.