Current guideline-based criteria defining COPD do not meet the challenges set by the complex pathophysiology of the disease. Hyperinflation and affection of the small airways are two components that are not represented in current diagnostic concepts and may relate to early stages of the disease. Moreover, optimal therapeutic interventions in patients with these distinct features remain unclear. The investigators therefore aimed to evaluate novel or not widely used diagnostic approaches for the detection and initiating therapeutic strategies in early stage COPD within the GOLD recommendations.
Study Type
OBSERVATIONAL
Enrollment
26
within indication according to current GOLD recommendation
within indication according to current GOLD recommendation
University Medical Center Mannheim
Mannheim, Germany
residual volume
change in residual volume from baseline
Time frame: 8 weeks
D5-20
change in frequency dependence of resistance from baseline
Time frame: 8 weeks
LCI
change in lung clearance index from baseline
Time frame: 8 weeks
tpeak
increase in exercise duration from baseline
Time frame: 8 weeks
IC
increase in inspiratory capacity (isotime and resting) from baseline
Time frame: 8 weeks
SGRQ
improvement in St. George's Respiratory Questionaire from baseline
Time frame: 8 weeks
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