The focus of the study is the pathophysiological mechanism of allo-antibody formation after red blood cell transfusion in sickle cell disease patients.
The main objectives of this study are to study the role of the innate and adaptive immune response in allo-antibody formation and furthermore to identify the genetic and time dependent clinical risk factors on alloimmunization in SCD patients. Subjects without allo-antibodies, receiving a red blood cell transfusion, will be included in this study. At 5 time points blood will be drawn from these subjects. (T0: Before transfusion, T1: 1 day after transfusion, T2: 1 week after transfusion, T3: 4 weeks after transfusion, T4: 6 months after transfusion). At each time point specific markers of the immune system will be measured.
Study Type
OBSERVATIONAL
Enrollment
150
Academic Medical Center Amsterdam
Amsterdam-Zuidoost, Netherlands
RECRUITINGRadboudumc
Nijmegen, Netherlands
RECRUITINGErasmus MC
Rotterdam, Netherlands
RECRUITINGThe innate and adaptive immune response of patients with sickle cell disease that form allo-antibodies following erythrocyte transfusion, compared to patients that do not form alloantibodies following erythrocyte transfusion
Multiple activating and regulatory markers of the innate and adaptive immune system will be measured at the indicated time points and compared between cases and controls
Time frame: 6 months
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HagaZiekenhuis
The Hague, Netherlands
NOT_YET_RECRUITING